反应详情

温度

40 °C

A suspension of 10.0 g (28 mmol) of 2′-phthalimidomethylbiphenyl-2-carboxylic acid in 450 ml of methanol was treated with 20 ml of hydrazine hydrate and heated at 40° C. for 1.5 h. The reaction mixture was concentrated and the residue was taken up in 250 ml of methylene chloride. After filtering off undissolved 2,3-dihydrophthalazine-1,4-dione, the mother liquor was concentrated and 4.8 g of 2′-aminomethylbiphenyl-2-carboxylic acid were obtained.

1. concentrationThe reaction mixture was concentrated
2. filtrationAfter filtering off undissolved 2,3-dihydrophthalazine-1,4-dione
3. concentrationthe mother liquor was concentrated