Dimethyl Sulfoxide → 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(2,2-dioxidohexahydropyrazino[2,1-c][1,4]thiazin-8(1H)-yl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide
Reaction equation
[C:49](=[O:50])([O-:51])[O-:52].[CH2:37]1[S:38](=[O:47])(=[O:48])[CH2:39][CH2:40][N:41]2[CH:42]1[CH2:43][NH:44][CH2:45][CH2:46]2.[CH3:55][S:56]([CH3:57])=[O:58].[CH3:60][CH2:61][O:62][C:63](=[O:64])[CH3:65].[F:1][C:2]([c:3]1[cH:4][c:5]([C:13]([C:14](=[O:15])[N:16]([CH3:17])[c:18]2[cH:19][n:20][c:21]([Cl:32])[cH:22][c:23]2-[c:24]2[c:25]([CH3:31])[cH:26][c:27]([F:30])[cH:28][cH:29]2)([CH3:33])[CH3:34])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:35])[F:36].[K+:53].[K+:54].[OH2:59]>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:13]([C:14](=[O:15])[N:16]([CH3:17])[c:18]2[cH:19][n:20][c:21]([N:44]3[CH2:43][CH:42]4[CH2:37][S:38](=[O:47])(=[O:48])[CH2:39][CH2:40][N:41]4[CH2:46][CH2:45]3)[cH:22][c:23]2-[c:24]2[c:25]([CH3:31])[cH:26][c:27]([F:30])[cH:28][cH:29]2)([CH3:33])[CH3:34])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:35])[F:36]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-c8b4d634efc749b1b7460f3ee41cc787
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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