Acetonitrile → HCID 67316482, compound

HRID 1014620Notes

Reaction equation

HRID 1014620 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=1[CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH:10]=[O:11].[C:19](#[N:21])[CH3:20]>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=1[CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH:10]([OH:11])[CH2:20][C:19]#[N:21])[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 197446743-[(2-Methoxybenzyl)oxy]benzaldehyde

Product 1

HCID 67316482HCID 67316482, compound

Procedure

Addition of acetonitrile to 3-(2-methoxybenzyloxy)benzaldehyde gave 3-(3-(2-methoxybenzyloxy)phenyl)-3-hydroxypropanenitrile as yellow oil. Yield (0.88 g, 47%): NMR (400 MHz, CDCl3) δ 7.42-7.46 (m, 1H), 7.27-7.31 (m, 2H), 6.90-7.06 (m, 5H), 5.12 (s, 2H), 5.01 (m, 1H), 3.87 (s, 3H), 2.76-2.82 (m, 2H).

Sources & evidence

ORD record
ord-692aea7b6c9a4367a749c2ed838ddc57
Source dataset
uspto-grants-2011_07
Patent number
US07982071B2

Reaction notes

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