HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[2-(3-Methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 15895837 | HCID 15895837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[2-(3-Methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride | HCID 66985076 | 57% |
Reaction Steps
To a solution of 1-[2-(3-methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine in ethanol is added 6 N hydrogen chloride aqueous solution until the pH is 3. The resulting solution is allowed to stand at ambient temperature overnight. The resultant crystals were filtered, washed with cold ethanol, and dried to give 61 mg of the title compound (57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07985751B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-acabb651bdc547bfbaa88e384b213d78 |
| Source note | uspto-grants-2011_07 |