Hydrochloric Acid → 1-[2-(3-Methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

HRID 1014949Notes

Reaction equation

HRID 1014949 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[OH:9].[ClH:27]>C(O)C>[ClH:27].[ClH:27].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:16][CH2:17]2)[CH:6]=[CH:7][C:8]=1[OH:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15895837HCID 15895837, compound

Product 1

HCID 669850761-[2-(3-Methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochlorideYield 57%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-[2-(3-methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine in ethanol is added 6 N hydrogen chloride aqueous solution until the pH is 3. The resulting solution is allowed to stand at ambient temperature overnight. The resultant crystals were filtered, washed with cold ethanol, and dried to give 61 mg of the title compound (57%).

Workup

  1. filtrationThe resultant crystals were filtered
  2. washwashed with cold ethanol
  3. customdried

Sources & evidence

ORD record
ord-acabb651bdc547bfbaa88e384b213d78
Source dataset
uspto-grants-2011_07
Patent number
US07985751B2

Reaction notes

Loading…