反应详情

To a solution of acryloyl chloride (5.0 g, 55.2 mmol) and 3-methyl-3-pentanol (7.6 ml, 60.8 mmol) in dichloromethane, triethylamine (23 ml, 166 mmol) was added at room temperature under a nitrogen atmosphere. After stirring at room temperature for 14 hours, the reaction mixture was diluted with dichloromethane and washed with water and saturated aqueous sodium chloride. The organic layer was dried over anhydrous sodium sulfate. After evaporation under reduced pressure to remove the solvent, the resulting residue was purified by column chromatography (hexane:ethyl acetate=10:1) to give the titled compound (5.45 g, 63%) as a colorless oil.

1. washwashed with water and saturated aqueous sodium chloride
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customAfter evaporation under reduced pressure
4. customto remove the solvent
5. customthe resulting residue was purified by column chromatography (hexane:ethyl acetate=10:1)