Hydrochloric Acid → HCID 58416421, compound

HRID 1014997Notes

Reaction equation

HRID 1014997 reaction equation
[CH3:1][C:2]1([C:7]2[C:8]([CH2:13][CH2:14][NH2:15])=[N:9][CH:10]=[CH:11][CH:12]=2)OCCO1.Cl.[OH-].[Na+]>>[CH3:1][C:2]1[C:7]2[CH:12]=[CH:11][CH:10]=[N:9][C:8]=2[CH2:13][CH2:14][N:15]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58416509HCID 58416509, compound

Product 1

HCID 58416421HCID 58416421, compound

Conditions

Temperature
100 °C

Procedure

2-[3-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-ethylamine (490 mg, 2.35 mmol, 1.0 equiv) is dissolved in 1N HCl solution (47 mL, 47.0 mmol, 20.0 equiv) and heated at 100° C. for 2 hours. According to TLC analysis the reaction is completed. The mixture is cooled and 1N NaOH solution is added. The mixture is extracted twice with dichloromethane, washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. This gave the title compound.

Workup

  1. temperatureThe mixture is cooled
  2. extractionThe mixture is extracted twice with dichloromethane
  3. washwashed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-31401129cc834e7183589a23568932f3
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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