Phosphorus oxide (P4O10) → 1-Methyl-3,4-dihydroisoquinoline

HRID 1015032Notes

Reaction equation

HRID 1015032 reaction equation
[CH2:1]([NH:9][C:10](=O)[CH3:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:11][C:10]1[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2][CH2:1][N:9]=1

Participants

3

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 70143N-(2-phenylethyl)acetamide

Product 1

HCID 2315021-Methyl-3,4-dihydroisoquinoline

Procedure

In close analogy to the procedure described above, N-phenethyl-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record
ord-0b1146578704439490c07767eb4748c9
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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