Phosphorus oxide (P4O10) → 5-Methoxy-1-methyl-3,4-dihydroisoquinoline

HRID 1015040Notes

Reaction equation

HRID 1015040 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][C:12](=O)[CH3:13].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:4]=1[CH2:9][CH2:10][N:11]=[C:12]2[CH3:13]

Participants

3

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 4053755N-[2-(2-methoxyphenyl)ethyl]acetamide

Product 1

HCID 450911955-Methoxy-1-methyl-3,4-dihydroisoquinoline

Procedure

In close analogy to the procedure described above, N-[2-(2-methoxy-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record
ord-960451b4c21e46e08e30f2549d789984
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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