Sodium triacetoxyborohydride → 6-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline

HRID 1015055Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:12])=[N:7][CH2:6][CH2:5]2.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH3:12])[NH:7][CH2:6][CH2:5]2

Participants

Reactant 2

HCID 5049666Sodium triacetoxyborohydride

HCID 58416341HCID 58416341, compound

Product 1

HCID 115138056-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline

Procedure

In close analogy to the procedure described above, 6-fluoro-1-methyl-3,4-dihydro-isoquinoline is reacted with sodium triacetoxyborohydride to provide the title compound.

Sources & evidence

ORD record: ord-c6876bc8beae44c793f069034c83f679
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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