Boronic Acid → 1-Methyl-5-pyridin-3-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015076Notes

Reaction equation

HRID 1015076 reaction equation
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH:7]2[CH3:12].B(O)O>>[CH3:12][CH:7]1[C:8]2[C:3](=[C:2]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:3]=3)[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:5][NH:6]1

Participants

3

Reactant 2

HCID 61668Boronic AcidHCID 596625945-Bromo-1,2,3,4-tetrahydro-1-methylisoquinoline

Product 1

HCID 584163751-Methyl-5-pyridin-3-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 5-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Sources & evidence

ORD record
ord-6b46537555824dcf98ccdc6682dda24b
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…