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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1015375Generated: October 31, 2026

2,6-Difluorobenzonitrile → HCID 67301356, compound

https://huagongshe.com/reaction/1015375

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-DifluorobenzonitrileHCID 74695—
ReactantPotassium tert-butoxideHCID 23665647—
ReactantHCID 67301499HCID 67301499—
SolventDimethylformamideHCID 6228—
ProductHCID 67301356HCID 67301356100%

Reaction Steps

4-(2-Chlorobenzyl)cyclohexylmethanol (68 mg; 0.28 mmol) and 2,6-difluorobenzonitrile (40 mg; 0.28 mmol) were carried out using Method I with potassium t-butoxide (35 mg; 0.31 mmol) in 1.5 mL of dimethylformamide. Material was purified by flash chromatography to give 100 mgs of title compound as a colorless oil. (100% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07985755B2
Source datasetuspto-grants-2011_07
ORD IDord-b317d9d8f7a5405198a03d1f71792ea0
Source noteuspto-grants-2011_07