2,6-Difluorobenzonitrile → HCID 67301356, compound

HRID 1015375Notes

Reaction equation

HRID 1015375 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][CH:5]1[CH2:10][CH2:9][CH:8]([CH2:11][OH:12])[CH2:7][CH2:6]1.[F:17][C:18]1[CH:25]=[CH:24][CH:23]=[C:22](F)[C:19]=1[C:20]#[N:21].CC(C)([O-])C.[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][CH:5]1[CH2:6][CH2:7][CH:8]([CH2:11][O:12][C:22]2[CH:23]=[CH:24][CH:25]=[C:18]([F:17])[C:19]=2[C:20]#[N:21])[CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 746952,6-DifluorobenzonitrileHCID 23665647Potassium tert-butoxideHCID 67301499HCID 67301499, compound

Product 1

HCID 67301356HCID 67301356, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-(2-Chlorobenzyl)cyclohexylmethanol (68 mg; 0.28 mmol) and 2,6-difluorobenzonitrile (40 mg; 0.28 mmol) were carried out using Method I with potassium t-butoxide (35 mg; 0.31 mmol) in 1.5 mL of dimethylformamide. Material was purified by flash chromatography to give 100 mgs of title compound as a colorless oil. (100% yield).

Workup

  1. customMaterial was purified by flash chromatography

Sources & evidence

ORD record
ord-b317d9d8f7a5405198a03d1f71792ea0
Source dataset
uspto-grants-2011_07
Patent number
US07985755B2

Reaction notes

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