Trifluoroacetic acid → HCID 67301351, compound

HRID 1015418Notes

Reaction equation

HRID 1015418 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:18]=2[C:19]([NH2:28])=[N:20][C:21]([NH2:27])=[N:22]3)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>ClCCl>[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[N:11]1([CH2:14][CH2:15][O:16][C:17]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:18]=2[C:19]([NH2:28])=[N:20][C:21]([NH2:27])=[N:22]3)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 25006303HCID 25006303, compound

Product 1

HCID 67301351HCID 67301351, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a 100 mL round bottom flask 4-[2-(2,4-Diamino-quinazolin-5-yloxy)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (2.3 g; 5.9 mmol) was magnetically stirred in 20 mL of dichloromethane and trifluoroacetic acid (3 mL) was added dropwise at room temperature. After 16 hours, solids were filtered and rinsed with 10 mls of dichloromethane. Title compound was obtained 2.1 g (88% yield).

Workup

  1. filtrationsolids were filtered
  2. washrinsed with 10 mls of dichloromethane

Sources & evidence

ORD record
ord-84766521af704f35b953ffd4cee957d4
Source dataset
uspto-grants-2011_07
Patent number
US07985755B2

Reaction notes

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