反应详情

温度

100 °C

A 234 mg portion of ethyl 2,3-dimethyl-1H-indole-5-carboxylate was dissolved in 1 ml of toluene, and 0.145 ml of iodobenzene and 10 mg of copper(I) iodide and 480 mg of tripotassium phosphate and 26 ml of trans-1,2-cyclohexanediamine were added at room temperature, followed by stirring at 100° C. for 24 hours. After evaporation of the solvent under a reduced pressure, the residue was purified by silica gel column chromatography (hexane-ethyl acetate:hexane=1:4) to obtain 79 mg of ethyl 2,3-dimethyl-1-phenyl-1H-indole-5-carboxylate as a colorless oily material.

1. customAfter evaporation of the solvent under a reduced pressure
2. customthe residue was purified by silica gel column chromatography (hexane-ethyl acetate:hexane=1:4)