Trifluoromethanesulfonic acid → 5-Phenyladamantan-2-one

HRID 1015500Notes

Reaction equation

HRID 1015500 reaction equation
O[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C:5]3=[O:12])[CH2:3]1)[CH2:9]2.OS(C(F)(F)F)(=O)=O>C1C=CC=CC=1>[C:2]1([C:2]23[CH2:11][CH:6]4[CH2:7][CH:8]([CH2:10][CH:4]([C:5]4=[O:12])[CH2:3]2)[CH2:9]3)[CH:11]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 62406Trifluoromethanesulfonic acidHCID 64184Idramantone

Product 1

HCID 128135085-Phenyladamantan-2-one

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Friedel Crafts reaction of benzene with 5-hydroxy adamantanone in presence of triflic acid over a period of about 1-4 h at reflux temperature to obtain 5-phenyl adamantan one.

Workup

  1. temperatureat reflux temperature

Sources & evidence

ORD record
ord-e3d7ea12b30a402798603cda76dc7352
Source dataset
uspto-grants-2011_07
Patent number
US07985759B2

Reaction notes

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