Propylamine → HCID 24772472, compound

HRID 1015590Notes

Reaction equation

[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:17])([CH3:16])[O:12][C:13]([CH3:15])([CH3:14])[C:9]=2[C:8]=1[C:19]([OH:21])=O)=[O:5].[CH2:30]([NH2:33])[CH2:31][CH3:32]>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:17])([CH3:16])[O:12][C:13]([CH3:14])([CH3:15])[C:9]=2[C:8]=1[C:19]([NH:33][CH2:30][CH2:31][CH3:32])=[O:21])=[O:5]

Participants

Reactant 2

HCID 7852Propylamine

HCID 67300640HCID 67300640, compound

Product 1

HCID 24772472HCID 24772472, compound

Procedure

The title compound was prepared from the product of Example 45A and propylamine using the procedure described in Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 0.85 (t, J=7.3 Hz, 3H), 1.42-1.49 (m, 2H), 1.44 (s, 6H), 1.48 (s, 6H), 3.08-3.14 (m, 2H), 7.67-7.8 (m, 3H), 8.05 (t, J=5.4 Hz, 1H), 11.54 (br s, 1H). MS (ESI+) m/z 473 (M+H)+. Anal. calcd. for C22H24F4N2O3S: C, 55.92; H, 5.12; N, 5.93. Found: C, 55.39; H, 4.65; N, 5.69.

Sources & evidence

ORD record: ord-ac71c2d1f954428e83ef1b08523cb610
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985768B2

Reaction notes

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