Ethanolamine → HCID 24772744, compound

HRID 1015610Notes

Reaction equation

[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:17])([CH3:16])[O:12][C:13]([CH3:15])([CH3:14])[C:9]=2[C:8]=1[C:19]([OH:21])=O)=[O:5].[OH:30][CH2:31][CH2:32][NH2:33]>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:27])([F:28])[F:29])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:16])([CH3:17])[O:12][C:13]([CH3:14])([CH3:15])[C:9]=2[C:8]=1[C:19]([NH:33][CH2:32][CH2:31][OH:30])=[O:21])=[O:5]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 67300640HCID 67300640, compound

Product 1

HCID 24772744HCID 24772744, compound

Procedure

The title compound was prepared from the product of Example 45A and commercially available 2-hydroxyethylamine using the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.45 (s, 6H), 1.48 (s, 6H), 3.24 (q, J=6.2 Hz, 2H), 3.43 (q, J=5.6 Hz, 2H), 4.65 (t, J=5.6 Hz, 1H), 7.68-7.81 (m, 3H), 7.89 (t, J=5.6 Hz, 1H), 11.58 (br s, 1H). MS (ESI+) m/z 475 (M+H)+.

Sources & evidence

ORD record: ord-3c875c7182764e019f982f36378ece69
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985768B2

Reaction notes

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