1,4-Dioxane hydrochloride → HCID 66877048, compound

HRID 1015789Notes

Reaction equation

HRID 1015789 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][S:5]([C:8]1[CH:22]=[CH:21][CH:20]=[CH:19][C:9]=1[CH2:10][NH:11]C(=O)OC(C)(C)C)(=[O:7])=[O:6].O1CCOCC1.[ClH:29]>C(OCC)(=O)C>[ClH:29].[CH3:1][O:2][CH2:3][CH2:4][S:5]([C:8]1[CH:22]=[CH:21][CH:20]=[CH:19][C:9]=1[CH2:10][NH2:11])(=[O:6])=[O:7]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86650833HCID 86650833, compound

Product 1

HCID 66877048HCID 66877048, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(Step 4) tert-Butyl {2-[(2-methoxyethyl)sulfonyl]benzyl}carbamate obtained in Step 3 (15.0 g) was dissolved in ethyl acetate (91 ml), and 4N hydrogen chloride-1,4-dioxane solution (34.2 ml) was added at 0° C. The mixture was stirred at room temperature for 12 hr, and the precipitated crystals were collected by filtration, and washed with ethyl acetate to give 1-{2-[(2-methoxyethyl)sulfonyl]phenyl}methanamine hydrochloride (10.0 g).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-a201c85ef4c043c5baadb221f839792c
Source dataset
uspto-grants-2011_07
Patent number
US07985862B2

Reaction notes

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