HCID 16784866, compound → HCID 66877728, compound

HRID 1015904Notes

Reaction equation

HRID 1015904 reaction equation
[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:15][NH2:16])(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCOCC1.[ClH:23]>C(OCC)(=O)C>[ClH:23].[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:15][NH2:16])(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 16784866HCID 16784866, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 66877728HCID 66877728, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(Step 3) 1-[2-(Pyrrolidin-1-ylsulfonyl)phenyl]methanamine obtained in Step 2 (3.88 g) was dissolved in ethyl acetate (32 ml), and 4N hydrogen chloride-1,4-dioxane solution (16 ml) was added at 0° C. The mixture was stirred at room temperature for 1 hr, and the precipitated crystals were collected by filtration, and washed with ethyl acetate to give 1-[2-(pyrrolidin-1-ylsulfonyl)phenyl]methanamine hydrochloride (4.07 g).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-548afb9bc15147958478f957268e6aeb
Source dataset
uspto-grants-2011_07
Patent number
US07985863B2

Reaction notes

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