HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-(hydroxymethyl)phenol → (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-(hydroxymethyl)phenol | HCID 10606838 | — |
| Reactant | Triphenylphosphonium hydrobromide | HCID 22178555 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide | HCID 86638793 | — |
Reaction Steps
In 186 ml of acetonitrile, 18.6 g (130.87 mmol) of 4-fluoro-2-(hydroxymethyl)phenol and 42.67 g (124.32 mmol) of triphenylphosphonium hydrobromide are stirred under reflux for 3 h. After cooling, the precipitate formed is filtered off with suction and dried. This gives 58 g (124 mmol, 100% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07985876B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-76c9457c1212430b9ee04f3077ce7db9 |
| Source note | uspto-grants-2011_07 |