反应详情

温度

60 °C

280 mg (1.2 mmol) of 1-(bromomethyl)-4-(trifluoromethyl)benzene and 162 mg (1.2 mmol) of anhydrous potassium carbonate are added to a solution of 279 mg (0.59 mmol) of methyl 4-[(4E)-5-(5-fluoro-2-hydroxyphenyl)-3-{2-[4-(methoxycarbonyl)phenyl]ethyl} pent-4-en-1-yl]benzoate in 6.5 ml of dry acetonitrile, and the mixture is then heated at 60° C. for 12 hours. The mixture is then filtered, and the filtrate is evaporated to dryness. The residue is purified by preparative HPLC. This gives 274 mg (0.43 mmol, 74% of theory) of a colorless oil.

1. filtrationThe mixture is then filtered
2. customthe filtrate is evaporated to dryness
3. customThe residue is purified by preparative HPLC