Hydrochloric Acid → HCID 67299615, compound

HRID 1016091Notes

Reaction equation

HRID 1016091 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([C:15](=[O:27])[C@H:16]([NH:19]C(=O)OC(C)(C)C)[CH2:17][CH3:18])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>O1CCOCC1>[ClH:2].[NH2:19][C@H:16]([CH2:17][CH3:18])[C:15]([N:12]1[CH2:13][CH2:14][CH:9]([C:6]2[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57888901HCID 57888901, compound

Product 1

HCID 67299615HCID 67299615, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 4M solution of HCl in dioxane (8 mL) was added to (R)-tert-butyl 1-(4-(4-chlorophenyl)piperidin-1-yl)-1-oxobutan-2-ylcarbamate (0.46 g) and the resulting solution was allowed to stir at rt. for 1.5 h. After this time, the solvent was removed by rotary evaporation to provide an oil. The oil was dried overnight in vacuo to provide (R)-2-amino-1-(4-(4-chlorophenyl)piperidin-1-yl)butan-1-one hydrochloride. MS found: (M+H)+=281.

Workup

  1. customAfter this time, the solvent was removed by rotary evaporation
  2. customto provide an oil
  3. customThe oil was dried overnight in vacuo

Sources & evidence

ORD record
ord-3b01ae044f1b4a76b8f7284926db2da1
Source dataset
uspto-grants-2011_07
Patent number
US07985861B2

Reaction notes

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