反应详情

A solution of 3-(chlorosulfonyl)benzoic acid (152 mg, 0.689 mmol) in methylene chloride (2 mL) was treated with 2.0 M dimethylamine in THF (1.137 mL, 2.274 mmol), and the mixture was stirred overnight at room temperature. The reaction was quenched with 1 N HCl, and extracted 3× with EtOAc. The combined organic phases were washed with 1 N HCl followed by brine, then dried over sodium sulfate and concentrated in-vacuo to yield the title compound (138 mg, 0.602 mmol, 87% yield). MS (ESI+)=230.18, (M+H)+.

1. customThe reaction was quenched with 1 N HCl
2. extractionextracted 3× with EtOAc
3. washThe combined organic phases were washed with 1 N HCl
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in-vacuo