反应详情

To a solution of ethyl 2-aminooxazole-4-carboxylate (1.56 g, 9.99 mmol) in THF (4 mL) and MeOH (4 mL), was added sodium hydroxide (8.0 g, 20 mmol, 10%) aq solution. The reaction was stirred at rt for 18 h then quenched with 4N HCl to pH=3. The aqueous solution was concentrated to give a yellow solid as a mixed acid and salts. The mixture was washed with EtOAc and MeOH, and the filtrate was collected and concentrated to give sodium 2-aminooxazole-4-carboxylate as a yellow solid.

1. customthen quenched with 4N HCl to pH=3
2. concentrationThe aqueous solution was concentrated
3. customto give a yellow solid as a mixed acid and salts
4. washThe mixture was washed with EtOAc and MeOH
5. customthe filtrate was collected
6. concentrationconcentrated