HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 1-Ethoxy-2,3-difluoro-4-(4-pentylcyclohex-3-enyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 4-(4-Ethoxy-2,3-difluorophenyl)-1-pentylcyclohexanol | HCID 11324866 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Ethoxy-2,3-difluoro-4-(4-pentylcyclohex-3-enyl)benzene | HCID 11415601 | — |
Reaction Steps
A solution of 128.0 g of 4-(4-ethoxy-2,3-difluoro-phenyl)-1-pentylcyclohexanol in 11 of toluene was refluxed in a water separator with addition of 5.0 g of toluene-4-sulphonic acid monohydrate. When all the water had been removed, the mixture was subjected to conventional work-up, giving 1-ethoxy-2,3-difluoro-4-(4-pentylcyclohex-3-enyl)benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06475595B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-535eb4120ee44aa49a7a88526e014ea5 |
| Source note | uspto-grants-2002_11 |