反应详情

8.5 g of (+/−)-cis-1,2-dimethoxy-4-(2-nitrocyclohexyl)benzene are dissolved in 400 ml of methanol and treated at RT with 7 ml of hydrazine hydrate and 2.5 g of Raney nickel in portions in the course of 8 h. After stirring overnight at RT, the reaction mixture is filtered, the filtrate is concentrated and the residue is chromatographed on silica gel using a mixture of toluene/ethyl acetate/triethylamine=4/2/0.5. The title compound is obtained as an oil.

1. filtrationthe reaction mixture is filtered
2. concentrationthe filtrate is concentrated
3. customthe residue is chromatographed on silica gel using
4. additiona mixture of toluene/ethyl acetate/triethylamine=4/2/0.5