HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Chloromethyl)pyridine hydrochloride → 10-bromo-2-(3-pyridylmethyl)-5-(3-pyridylmethyloxy)-3H-pyrido[3,2,1-kl]phenothiazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Chloromethyl)pyridine hydrochloride | HCID 23394 | — |
| Reactant | 10-bromo-5-hydroxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one | HCID 12021105 | — |
| Product | 10-bromo-2-(3-pyridylmethyl)-5-(3-pyridylmethyloxy)-3H-pyrido[3,2,1-kl]phenothiazin-3-one | HCID 12021107 | 46% |
Reaction Steps
According to Example 34, the compound (300 mg) produced in Example 37 was reacted with 3-chloromethylpyridine hydrochloride (142 mg) to obtain the title compound (140 mg; 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476021B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-520fd9fafe6b4961a51fa510b55c0224 |
| Source note | uspto-grants-2002_11 |