HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)pyridinium chloride → 10-bromo-2-(3-pyridylmethyl)-5-(4-pyridylmethyloxy)-3H-pyrido[3,2,1-kl]phenothiazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| Reactant | 10-bromo-5-hydroxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one | HCID 12021105 | — |
| Product | 10-bromo-2-(3-pyridylmethyl)-5-(4-pyridylmethyloxy)-3H-pyrido[3,2,1-kl]phenothiazin-3-one | HCID 12021110 | 54.1% |
Reaction Steps
According to Example 34, the compound (150 mg) produced in Example 37 was reacted with 4-chloromethylpyridine hydrochloride (84 mg) to obtain the title compound (98 mg; 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476021B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-48d24e38dcf54eca82766fcb9ae5e0af |
| Source note | uspto-grants-2002_11 |