Benzyl Chloride → 10-bromo-5-benzyloxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one

HRID 1016314Notes

Reaction equation

HRID 1016314 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([OH:16])[CH:10]=3.[CH2:28](Cl)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:16][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH:10]=3

Participants

3

Reactant 2

HCID 7503Benzyl ChlorideHCID 1202110510-bromo-5-hydroxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one

Product 1

HCID 1202111210-bromo-5-benzyloxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-oneYield 48%

Procedure

According to Example 34, the compound (100 mg) produced in Example 37 was reacted with benzyl chloride (39 μl) to obtain the title compound (58 mg; 48%).

Sources & evidence

ORD record
ord-b713a2b4b297468c85b6cff66a7829b9
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

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