HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1) → 10-bromo-5-(1-methyl-hexahydroazepin-4-yloxy)-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1) | HCID 3017050 | — |
| Reactant | 10-bromo-5-hydroxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one | HCID 12021105 | — |
| Product | 10-bromo-5-(1-methyl-hexahydroazepin-4-yloxy)-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one | HCID 18406591 | 37% |
Reaction Steps
According to Example 34, the compound (100 mg) produced in Example 37 was reacted with 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (54 mg) to obtain the ring expanding title compound (46 mg; 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476021B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-8a2f42c214314d5fa165445afacbf028 |
| Source note | uspto-grants-2002_11 |