Hydrochloric Acid → HCID 136378091, compound

HRID 1016359Notes

Reaction equation

HRID 1016359 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:20]1[NH:25][C:24](=[O:26])[C:23]2=[C:27]([CH3:35])[N:28]=[C:29]([CH:30]3[CH2:34][CH2:33][CH2:32][CH2:31]3)[N:22]2[N:21]=1)[CH3:2].[ClH:36]>C(OCC)C>[ClH:36].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][NH:16][CH2:19][CH:14]2[CH3:15])(=[O:12])=[O:11])=[CH:6][C:5]=1[C:20]1[NH:25][C:24](=[O:26])[C:23]2=[C:27]([CH3:35])[N:28]=[C:29]([CH:30]3[CH2:31][CH2:32][CH2:33][CH2:34]3)[N:22]2[N:21]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 135456038HCID 135456038, compound

Product 1

HCID 136378091HCID 136378091, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

220 mg (0.42 mmol) of 2-[2-ethoxy-5-(4-methylpiperazine-1-sulphonyl)-phenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,-f][1,2,4]-triazin-4-one (Example 1) are suspended in 20 ml of diethyl ether and, after addition of 20 mg (0.462 mmol) of 1 molar ethereal HCl solution, stirred at room temperature for 30 minutes. The solvent is distilled off under reduced pressure and the residue is dried under high vacuum.

Workup

  1. distillationThe solvent is distilled off under reduced pressure
  2. customthe residue is dried under high vacuum

Sources & evidence

ORD record
ord-a68f4a8c18be455688c81eae76cd4018
Source dataset
uspto-grants-2002_11
Patent number
US06476029B1

Reaction notes

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