Thionyl Chloride → 5-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

HRID 1016394Notes

Reaction equation

HRID 1016394 reaction equation
[CH3:1][N:2]1[C:6]([CH2:7]O)=[N:5][CH:4]=[N:3]1.S(Cl)([Cl:11])=O>>[ClH:11].[Cl:11][CH2:7][C:6]1[N:2]([CH3:1])[N:3]=[CH:4][N:5]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 11073377(1-methyl-1H-1,2,4-triazol-5-yl)methanol

Product 1

HCID 222853325-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

Procedure

(2-Methyl-2H-[1,2,4]triazol-3-yl)methanol (1 g) was added in portions to thionyl chloride (20 ml) and the solution was stirred at room temperature for 30 mins. The reaction mixture was concentrated under vacuum and the residue was azeotroped with toluene (2×30 ml) and dried under high vacuum to leave a crude product (1.3 g) which was used in the next step without characterisation or further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customthe residue was azeotroped with toluene (2×30 ml)
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-faab44345635431e97048799e00cb3ad
Source dataset
uspto-grants-2002_11
Patent number
US06476030B1

Reaction notes

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