反应详情

(2-Methyl-2H-[1,2,4]triazol-3-yl)methanol (1 g) was added in portions to thionyl chloride (20 ml) and the solution was stirred at room temperature for 30 mins. The reaction mixture was concentrated under vacuum and the residue was azeotroped with toluene (2×30 ml) and dried under high vacuum to leave a crude product (1.3 g) which was used in the next step without characterisation or further purification.

1. concentrationThe reaction mixture was concentrated under vacuum
2. customthe residue was azeotroped with toluene (2×30 ml)
3. customdried under high vacuum