Thionyl Chloride → 5-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

Participants

Reaction Steps

(2-Methyl-2H-[1,2,4]triazol-3-yl)methanol (1 g) was added in portions to thionyl chloride (20 ml) and the solution was stirred at room temperature for 30 mins. The reaction mixture was concentrated under vacuum and the residue was azeotroped with toluene (2×30 ml) and dried under high vacuum to leave a crude product (1.3 g) which was used in the next step without characterisation or further purification.

Provenance & Evidence