反应详情

温度

100 °C

A mixture of 3-bromo-7-(2-fluorophenyl)-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine (81.8 mg, 0.202 mmol) and 2-(tributylstannyl)pyridine (0.1520 g, 0.413 mmol) in anhydrous 1,4-dioxane (8 ml) was degassed using three freeze-pump-thaw cycles. Tetrakis(triphenylphosphine)palladium(0) (32.5 mg, 0.0281 mmol) and copper(I) iodide (4.5 mg, 0.024 mmol) were added and the mixture was further degassed with one freeze-pump-thaw cycle before heating at 100° C. under nitrogen for 18 h. The mixture was filtered through glass fibre paper, washing well with ethyl acetate (25 ml). The filtrate was washed with saturated aqueous NaCl (10 ml), and the aqueous layer was further extracted with ethyl acetate (25 ml). The combined organic extracts were dried (Na2SO4) and evaporated in vacuo. The residue was purified bar flash chromatography (silica gel, 4% MeOH/CH2Cl2 and silica gel, 0-4% MeOH/EtOAc) to give 62.4 mg (77%) of the title compound as a white solid, mp=186-187° C. (CH2Cl2-EtOAc); 1H NMR (400 MHz, CDCl3) δ 3.79 (3H, s), 5.61 (2H, s), 7.20 (1H, m), 7.29 (1H, t, J=9.4 Hz), 7.40 (1H, td, J=7.6 and 0.8 Hz), 7.64 (1H, mn), 7.73 (1H, td, J=7.8 and 1.8 Hz), 7.80 (1H, m), 7.89 (1H, s), 7.94 (1H, d, J=8.0 Hz), 8.70 (1H, m), 10.30 (1H, s); MS (ES+) m/e 403 [MH]+. Anal. Found C, 59.76; H, 3.65; N, 27.65%. C20H15FN8O requires C, 59.70; H, 3.76; N, 27.85%.

1. customwas degassed
2. customthe mixture was further degassed with one freeze-pump-thaw cycle
3. filtrationThe mixture was filtered through glass fibre paper
4. washwashing well with ethyl acetate (25 ml)
5. washThe filtrate was washed with saturated aqueous NaCl (10 ml)
6. extractionthe aqueous layer was further extracted with ethyl acetate (25 ml)
7. dry with materialThe combined organic extracts were dried (Na2SO4)
8. customevaporated in vacuo
9. customThe residue was purified bar flash chromatography (silica gel, 4% MeOH/CH2Cl2 and silica gel, 0-4% MeOH/EtOAc)