反应详情

A mixture of 2 g of 4-(4-chloro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester, dioxane (1.5 mL), and 3N hydrochloric acid (1.0 mL, 4equiv.) was heated at reflux for 3.5 hours. The cooled mixture was made basic with saturated sodium carbonate solution and extracted with chloroform (3×10 mL). The combined extracts were dried over magnesium sulfate and concentrated under reduced pressure. The crude product (1.2 g) was an oil.

1. temperaturewas heated
2. temperatureat reflux for 3.5 hours
3. extractionextracted with chloroform (3×10 mL)
4. dry with materialThe combined extracts were dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure