Octylamine → HCID 512826, compound

HRID 1016512Notes

Reaction equation

HRID 1016512 reaction equation
[C:1]1(=[O:8])O[C:5](=[O:6])[CH:4]=[C:2]1[CH3:3].[CH2:9]([NH2:17])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>N1C=CC=CC=1>[CH3:3][C:2]1[C:1](=[O:8])[N:17]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:5](=[O:6])[CH:4]=1

Participants

4

Reactant 2

HCID 8143OctylamineHCID 12012Citraconic Anhydrides

Product 1

HCID 512826HCID 512826, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
90 °C

Procedure

A solution of citraconic anhydride (0.1 M) in pyridine (20 ml)was treated with octylamine (0.1 M). The reaction mixture was heated to 90° C. for six hours. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product.

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. extractionthe residue was extracted into ethyl acetate
  3. washThe ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid
  4. dry with materialdried over sodium sulphate
  5. concentrationfinally concentrated in vacuo
  6. customThe residue obtained
  7. customwas chromatographed over silica gel

Sources & evidence

ORD record
ord-8edd79e501f94a3d8d2e385151340b7f
Source dataset
uspto-grants-2002_11
Patent number
US06476053B1

Reaction notes

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