Octylamine → HCID 512833, compound

HRID 1016515Notes

Reaction equation

HRID 1016515 reaction equation
[CH2:1]([N:9]1[C:13](=[O:14])[CH:12]=[CH:11][C:10]1=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH2:16]([NH2:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].C(N(CC)CC)C>C(#N)C>[CH2:1]([N:9]1[C:10](=[O:15])[CH2:11][CH:12]([NH:24][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:13]1=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 8143OctylamineHCID 8471TriethylamineHCID 512829Octyl Maleimide

Product 1

HCID 512833HCID 512833, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of N-octyl maleimide (0.01 M) prepared as described in Example 10 above, octylamine (0.01 M), triethylamine [catalytic, 0.1 equivalent] in acetonitrile (25 ml) was stirred for 24 hours at room temperature. Acetonitrile was removed under vacuum to leave a residual liquid product which was flash chromatographed (25% ethyl acetate in petroleum ether) to yield a white solid as the desired product.

Workup

  1. customprepared
  2. customAcetonitrile was removed under vacuum
  3. customto leave a residual liquid product which
  4. customchromatographed (25% ethyl acetate in petroleum ether)

Sources & evidence

ORD record
ord-3d06ffd1b304450d865bd3c15fdb546b
Source dataset
uspto-grants-2002_11
Patent number
US06476053B1

Reaction notes

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