Triethylamine → HCID 512834, compound

HRID 1016516Notes

Reaction equation

HRID 1016516 reaction equation
[CH2:1]([N:11]1[C:15](=[O:16])[CH:14]=[CH:13][C:12]1=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[CH2:18]([NH2:28])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].C(N(CC)CC)C>C(#N)C>[CH2:1]([N:11]1[C:12](=[O:17])[CH2:13][CH:14]([NH:28][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:15]1=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 8916DecylamineHCID 512830N-decyl maleimide

Product 1

HCID 512834HCID 512834, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of N-decyl maleimide (0.01 M) prepared as described in Example 11 above, decylamine (0.01 M), triethylamine [catalytic, 0.1 equivalent] in acetonitrile (25 ml) was stirred for 24 hours at room temperature. Acetonitrile was removed under vacuum to leave a residual liquid product which was flash chromatographed (25% ethyl acetate in petroleum ether) to yield a white solid as the desired product.

Workup

  1. customprepared
  2. customAcetonitrile was removed under vacuum
  3. customto leave a residual liquid product which
  4. customchromatographed (25% ethyl acetate in petroleum ether)

Sources & evidence

ORD record
ord-be847b03861d417e9c6fb83c1e98a3a8
Source dataset
uspto-grants-2002_11
Patent number
US06476053B1

Reaction notes

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