Bromine → HCID 18407235, compound

HRID 1016556Notes

Reaction equation

HRID 1016556 reaction equation
[F:1][C:2]([F:19])([C:15]([F:18])([F:17])[F:16])[CH2:3][O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[CH2:9][CH2:8]2.[Br:20]Br>C(OCC)(=O)C>[Br:20][CH:9]1[CH2:8][C:7]2[C:11](=[CH:12][CH:13]=[C:5]([O:4][CH2:3][C:2]([F:19])([F:1])[C:15]([F:16])([F:17])[F:18])[CH:6]=2)[C:10]1=[O:14]

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 18407244HCID 18407244, compound

Product 1

HCID 18407235HCID 18407235, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

6.9 g of 5-(2,2,3,3,3-pentafluoropropoxy)-1-indanone are dissolved in 100 ml of ethyl acetate, and a solution of 3.9 g of bromine in 15 ml of ethyl acetate is added dropwise. The solution is briefly heated to reflux before the remainder of the bromine solution is added dropwise. It is then stirred at room temperature for 2 h. The reaction solution is concentrated in vacuo and affords 2-bromo-5-(2,2,3,3,3-pentafluoropropoxy)-1-indanone as an oil which is employed without further purification in the next stage.

Workup

  1. temperatureThe solution is briefly heated
  2. additionis added dropwise
  3. concentrationThe reaction solution is concentrated in vacuo

Sources & evidence

ORD record
ord-b068569f54ee41c2afd0c0064b64700d
Source dataset
uspto-grants-2002_11
Patent number
US06476059B1

Reaction notes

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