HCID 18407322, compound → (4-Aminomethyl-2-methoxy-phenoxy)acetic Acid

HRID 1016618Notes

Reaction equation

HRID 1016618 reaction equation
C(OC([NH:11][CH2:12][C:13]1[CH:23]=[CH:22][C:16]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[C:15]([O:24][CH3:25])[CH:14]=1)=O)C1C=CC=CC=1.[H][H]>CO.[Pd]>[NH2:11][CH2:12][C:13]1[CH:23]=[CH:22][C:16]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[C:15]([O:24][CH3:25])[CH:14]=1

Participants

5

Reactant 2

HCID 18407322HCID 18407322, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13876411(4-Aminomethyl-2-methoxy-phenoxy)acetic AcidYield 55%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 16 (0.276 g, 0.8 mmol) in MeOH (5 mL) was treated with 10% palladium on carbon (30 mg) and hydrogenated under a balloon of hydrogen for 30 min. The reaction mixture was filtrated and the filtrate was concentrated to give 17 as white solid (0.093 g, 55%) which was used to next step without further purification.

Workup

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-ce7cf16934c843f7b86c9c2ad4b58d2e
Source dataset
uspto-grants-2002_11
Patent number
US06476076B1

Reaction notes

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