Trifluoroacetic acid → HCID 18407325, compound

HRID 1016620Notes

Reaction equation

HRID 1016620 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][N:18]=[N+:19]=[N-:20])=[C:11]([O:21][CH3:22])[CH:10]=1)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>C(Cl)Cl>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[N:18]([CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][NH2:7])=[CH:10][C:11]=1[O:21][CH3:22])=[N+:19]=[N-:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22894244HCID 22894244, compound

Product 1

HCID 18407325HCID 18407325, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
100 °C

Procedure

A solution of 32 (0.103 g, 0.32 mmol) in CH2Cl2 (1 mL) was treated with trifluoroacetic acid and heated at 100° C. for 1 hr. The reaction mixture was concentrated in vacuo. The residue was diluted with toluene and concentrated in vacuo several times to give 33 as brown solid (0.115 g, 100%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additionThe residue was diluted with toluene
  3. concentrationconcentrated in vacuo several times

Sources & evidence

ORD record
ord-9165f51681084bd9ad363cb7cef383c8
Source dataset
uspto-grants-2002_11
Patent number
US06476076B1

Reaction notes

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