Hydrochloric Acid → 3-Ethyl-4-hydroxybenzaldehyde

TiCl4 (45.6 g, 238 mmol) was added slowly to a solution of 2-ethylphenol (15 g, 119 mmol) in CH2Cl2 (150 ml) was at 0° C. The mixture was warmed to room temperature and dichloromethyl methyl ether (18.3 ml, 200 mmol) was added (strong HCl evolution). The mixture was stirred for 4 h. at room temperature, subsequently cooled to 0° C. and 1M HCl (119 ml, 119 mmol) was added dropwise. The mixture was stirred for 10 min. and subsequently extracted with diethyl ether. The organic phase was washed with saturated NaHCO3 solution and with NaCl solution, dried, filtered and concentrated. The residue was purified by chromatography (SiO2, CH2Cl2=>CH2Cl2/MeOH 9:1). 3-Ethyl-4-hydroxy-benzaldehyde was obtained as a brown oil (7.97 g, 45%).

1. customwas at 0° C
2. temperaturesubsequently cooled to 0° C.
3. stirringThe mixture was stirred for 10 min.
4. extractionsubsequently extracted with diethyl ether
5. washThe organic phase was washed with saturated NaHCO3 solution and with NaCl solution
6. customdried
7. filtrationfiltered
8. concentrationconcentrated
9. customThe residue was purified by chromatography (SiO2, CH2Cl2=>CH2Cl2/MeOH 9:1)

ORD record

ord-52daac8fde744f63bd5bca37fa37a71d

Source dataset

uspto-grants-2002_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06476264B2