反应详情

A suspension of 3,5-dimethylanisole (13.60 g, 100 mmol), N-bromosuccinimide (18.35 g, 100 mmol) and 2,2′-azobis(2-methylpropionitrile) in CCl4 was heated under reflux for 1 h. The succinimide was filtered off, the filtrate was concentrated and the residue was chromatographed (SiO2, CH2Cl2/hexane 1:4). There were obtained 14.61 g (68%) of 1-bromomethyl-3-methoxy-5-methyl-benzene.

1. temperaturewas heated
2. temperatureunder reflux for 1 h
3. filtrationThe succinimide was filtered off
4. concentrationthe filtrate was concentrated
5. customthe residue was chromatographed (SiO2, CH2Cl2/hexane 1:4)