2-Thiopheneacetic acid → 2-[(2-Thienyl)acetamido]butyric acid isobutyl ester

HRID 1016842Notes

Reaction equation

HRID 1016842 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:9])=O.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 159702-Thiopheneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 544436822-[(2-Thienyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I′ above and using 2-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-22534fc149fe41b3bd755cf040a6d843
Source dataset
uspto-grants-2002_11
Patent number
US06476263B1

Reaction notes

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