Morpholine → 3-Bromo-4-morpholinobenzaldehyde

HRID 1017005Notes

Reaction equation

HRID 1017005 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1F)[CH:5]=[O:6].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+]>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[CH:5]=[O:6]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 11430Potassium CarbonateHCID 1736043-Bromo-4-fluorobenzaldehyde

Product 1

HCID 235060203-Bromo-4-morpholinobenzaldehydeYield 58.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

EX-604A) To a pyridine (15 mL) solution of 3-bromo4-fluorobenzaldehyde (1.0 g, 4.9 mmol) was added morpholine (0.5 mL, 5.7 mmol) and K2CO3 (0.69 g, 5.0 mmol), and the slurry was refluxed for 18 h. The solvent was removed. and the residue was partitioned between ethyl acetate and water. The organic layer was separated. dried (MgSO4) and evaporated to a yellow oil. Purification by flash chromatography on silica gel eluting with 15% ethyl acetate in hexane gave 0.77 g (58%) of the desired 3-bromo4-(4-morpholinyl)benzaldehyde product as an white solid. 1H NMR (CDCl3) δ3.18 (m, 4H), 3.90 (m, 4H), 7.10 (d, 1H), 7.78 (d, 1H), 8.07 (s, 1H), 9.83 (s, 1H).

Workup

  1. temperaturethe slurry was refluxed for 18 h
  2. customThe solvent was removed
  3. customand the residue was partitioned between ethyl acetate and water
  4. customThe organic layer was separated
  5. dry with materialdried (MgSO4)
  6. customevaporated to a yellow oil
  7. customPurification by flash chromatography on silica gel eluting with 15% ethyl acetate in hexane

Sources & evidence

ORD record
ord-65862a17847a4f69b1b3105acabea530
Source dataset
uspto-grants-2002_11
Patent number
US06476057B1

Reaction notes

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