HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1017096Generated: November 1, 2026
1,3-Dichloropropane → N-(2-(3-Chloropropoxy)-4-nitrophenyl)acetamide
https://huagongshe.com/reaction/1017096
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-Dichloropropane | HCID 8881 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(2-Hydroxy-4-nitrophenyl)acetamide | HCID 3749260 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2-(3-Chloropropoxy)-4-nitrophenyl)acetamide | HCID 18003912 | — |
Reaction Steps
A mixture of 98.1 g (0.5 mol) of N-(2-hydroxy4-nitrophenyl)acetamide (RN 121-88-0) and 69.2 g (0.5 mol) of potassium carbonate in 500 ml of dimethylformamide was heated with stirring at 50° C.; 113.0 g (1 mol) of 1,3-dichloropropane (RN 142-28-9) were then added and heating was continued at 50° C. for one hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06478827B1 |
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| Source dataset | uspto-grants-2002_11 |
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| ORD ID | ord-4494b608c331444aba8f77ec70f38060 |
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| Source note | uspto-grants-2002_11 |
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