Hydrochloric Acid → HCID 178518851, compound

HRID 1017177Notes

Reaction equation

HRID 1017177 reaction equation
Cl.[Cl:2][C:3]1[C:8]([O:9][C:10]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:7][C:6]([N:20]=[C:21]2[S:25][C:24](=[O:26])[N:23](C=O)[NH:22]2)=[C:5]([F:29])[CH:4]=1>CO.CC(C)=O>[Cl:2][C:3]1[C:8]([O:9][C:10]2[C:15]([C:16]([F:18])([F:19])[F:17])=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:7][C:6]([N:20]=[C:21]2[S:25][C:24](=[O:26])[NH:23][NH:22]2)=[C:5]([F:29])[CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178521674HCID 178521674, compound

Product 1

HCID 178518851HCID 178518851, compoundYield 36%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 887MethanolSolvent

Procedure

A solution of 10% hydrochloric acid in methanol (8 ml) was added to a solution of 5-[4-chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenylimino]-3-formyl-1,3,4-thiadiazolidin-2-one (33 g) in acetone (60 ml). After stirring for 0.5 hour, the solvents were removed and the residue processed. A minimal amount of ethanol was used to dissolved the residue and hexane added to induce crystallization. The crystals were filtered off and dried to give the product (1.0 g, 36%).

Workup

  1. customthe solvents were removed
  2. dissolutionto dissolved the residue and hexane
  3. additionadded
  4. customcrystallization
  5. filtrationThe crystals were filtered off
  6. customdried

Sources & evidence

ORD record
ord-023f4ae11516425a8c263a8ed77224ab
Source dataset
uspto-grants-2002_11
Patent number
US06479435B1

Reaction notes

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