HCID 22896174, compound → HCID 22896175, compound

HRID 1017190Notes

Reaction equation

HRID 1017190 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C@H:11]2[CH2:28][C@@:26]3([CH3:27])[C@@H:22]([CH2:23][CH2:24][C:25]3=[O:29])[C@H:21]3[C:12]2=[C:13]2[C:18]([CH2:19][CH2:20]3)=[CH:17][C:16](=[O:30])[CH2:15][CH2:14]2)=[CH:7][CH:6]=1.[Cl-].[S:32](=[CH2:35])(=[O:34])=[O:33]>C(Cl)Cl>[CH3:35][S:32]([O:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C@H:11]2[CH2:28][C@@:26]3([CH3:27])[C@@H:22]([CH2:23][CH2:24][C:25]3=[O:29])[C@H:21]3[C:12]2=[C:13]2[C:18]([CH2:19][CH2:20]3)=[CH:17][C:16](=[O:30])[CH2:15][CH2:14]2)=[CH:9][CH:10]=1)(=[O:34])=[O:33]

Participants

4

Reactant 2

HCID 22896174HCID 22896174, compoundHCID 23435324HCID 23435324, compound

Product 1

HCID 22896175HCID 22896175, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
2.5 °C

Procedure

To a solution of 3.41 g of 11β-[4-(3-hydroxypropyl)phenyl]estra-4.9-diene-3,17-dione prepared to preparation 1 in 30 ml of CH2Cl2, under inert atmosphere and at ambient temperature, 1.53 ml of TEA and 0.72 ml of sulfonyl methane chloride in solution in 2 ml of CH2Cl2 is added whilst maintaining the temperature at 0-5° C. and stirring at this temperature. After washing and drying it is evaporated under reduced pressure until 4.15 g of expected raw product is obtained.

Workup

  1. washAfter washing
  2. customdrying it
  3. customis evaporated under reduced pressure until 4.15 g of expected raw product
  4. customis obtained

Sources & evidence

ORD record
ord-6f159cab2fb146e281cfbc18a998bf7b
Source dataset
uspto-grants-2002_11
Patent number
US06479476B1

Reaction notes

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