反应详情

A suspension of 3-hydroxy-2-phenylpyridine (20 g, 116 mmol) in toluene (250 ml) was heated at reflux for 30 minutes. Benzyl bromide (20 ml) was added and the reaction mixture was heated at reflux for 6 hours then cooled using an ice bath. The solid residue was collected by filtration and washed twice with ether to give crude N-benzyl-3-hydroxy-2-phenylpyridinium bromide (36.5 g, 91%) which was used in the next step without further purification.

1. temperaturewas heated
2. temperatureat reflux for 30 minutes
3. temperaturethe reaction mixture was heated
4. temperatureat reflux for 6 hours
5. temperaturethen cooled
6. filtrationThe solid residue was collected by filtration
7. washwashed twice with ether